Article
Detection of circulating tumor DNA in patients with advanced non-small cell lung cancer.
Oncotarget - 10 Jan 2017
Yao Yu, Liu Jinghao, Li Lei, Yuan Yuan, Nan Kejun, Wu Xin, Zhang Zhenyu, Wu Yi, Li Xin, Zhu Jiaqi, Meng Xuehong, Wei Longgang, Chen Jun, Jiang Zhi
Abstract excerpt
Circulating tumor DNA (ctDNA) isolated from plasma has great potential in identification of gene mutation in non-small cell lung cancers (NSCLC), which is a non-invasive technique and can avoid the inherent shortcomings of tissue biopsy. However the ability of NGS to detect gene mutation in plasma ctDNA has not been broadly explored. To assess the diagnostic ability of ctDNA for the total mutation profile,...
Topics
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
- Case-Control Studies
- Circulating Tumor DNA
- DNA Mutational Analysis
- Female
- High-Throughput Nucleotide Sequencing
- Humans
- INDEL Mutation