Article
Phenotypic Variability of ANK2 Mutations in Patients With Inherited Primary Arrhythmia Syndromes.
Circulation journal : official journal of the Japanese Circulation Society - 25 Nov 2016
Ichikawa Mari, Aiba Takeshi, Ohno Seiko, Shigemizu Daichi, Ozawa Junichi, Sonoda Keiko, Fukuyama Megumi, Itoh Hideki, Miyamoto Yoshihiro, Tsunoda Tatsuhiko, Makiyama Takeru, Tanaka Toshihiro, Shimizu Wataru, Horie Minoru
Abstract excerpt
BACKGROUND: Mutations inANK2have been reported to cause various arrhythmia phenotypes. The prevalence ofANK2mutation carriers in inherited primary arrhythmia syndrome (IPAS), however, remains unknown in Japanese. Using a next-generation sequencer, we aimed to identifyANK2mutations in our cohort of IPAS patients, in whom conventional Sanger sequencing failed to identify pathogenic mutations in major causative...
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