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Article

A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages.

The FEBS journal - 1 Mar 2018

Chou Evelyn S, Abidi Sabia Z, Teye Marian, Leliwa-Sytek Aleksandra, Rask Thomas S, Cobbold Simon A, Tonkin-Hill Gerry Q, Subramaniam Krishanthi S, Sexton Anna E, Creek Darren J, Daily Johanna P, Duffy Michael F, Day Karen P

Abstract excerpt

Transient regulation of Plasmodium numbers below the density that induces fever has been observed in chronic malaria infections in humans. This species transcending control cannot be explained by immunity alone. Using an in vitro system we have observed density dependent regulation of malaria population size as a mechanism to possibly explain these in vivo observations. Specifically, Plasmodium falciparum blood...

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PMID: 29281179
DOI: 10.1111/febs.14370

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