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A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile

22 Oct 2016

Abstract excerpt

BACKGROUND: Clostridium difficile-associated disease (CDAD) constitutes a great majority of hospital diarrhea cases in industrialized countries and is induced by two types of large toxin molecules: toxin A (TcdA) and toxin B (TcdB). Development of immunotherapeutic approaches, either active or passive, has seen a resurgence in recent years. Studies have described vaccine plasmids that express either TcdA and/or...

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PMID: 27770789
DOI: 10.1186/s12879-016-1924-1

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