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Paternal and grandpaternal ages at conception and descendant telomere lengths in chimpanzees and humans

12 Oct 2016

Abstract excerpt

Telomeres are repeating DNA at chromosome ends. Telomere length (TL) declines with age in most human tissues, and shorter TL is thought to accelerate senescence. In contrast, older men have sperm with longer TL; correspondingly, older paternal age at conception (PAC) predicts longer TL in offspring. This PAC-effect could be a unique form of transgenerational genetic plasticity that modifies somatic maintenance in...

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PMID: 27731903
DOI: 10.1002/ajpa.23109

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