Article
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Nature genetics - 1 Nov 2016
Wang Jun, Thingholm Louise B, Skiecevičienė Jurgita, Rausch Philipp, Kummen Martin, Hov Johannes R, Degenhardt Frauke, Heinsen Femke-Anouska, Rühlemann Malte C, Szymczak Silke, Holm Kristian, Esko Tönu, Sun Jun, Pricop-Jeckstadt Mihaela, Al-Dury Samer, Bohov Pavol, Bethune Jörn, Sommer Felix, Ellinghaus David, Berge Rolf K, Hübenthal Matthias, Koch Manja, Schwarz Karin, Rimbach Gerald, Hübbe Patricia, Pan Wei-Hung, Sheibani-Tezerji Raheleh, Häsler Robert, Rosenstiel Philipp, D'Amato Mauro, Cloppenborg-Schmidt Katja, Künzel Sven, Laudes Matthias, Marschall Hanns-Ulrich, Lieb Wolfgang, Nöthlings Ute, Karlsen Tom H, Baines John F, Franke Andre
Abstract excerpt
Human gut microbiota is an important determinant for health and disease, and recent studies emphasize the numerous factors shaping its diversity. Here we performed a genome-wide association study (GWAS) of the gut microbiota using two cohorts from northern Germany totaling 1,812 individuals. Comprehensively controlling for diet and non-genetic parameters, we identify genome-wide significant associations for...
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