Article
Edible Safety Assessment of Genetically Modified Rice T1C-1 for Sprague Dawley Rats through Horizontal Gene Transfer, Allergenicity and Intestinal Microbiota.
PloS one - 1 Jan 2016
Zhao Kai, Ren Fangfang, Han Fangting, Liu Qiwen, Wu Guogan, Xu Yan, Zhang Jian, Wu Xiao, Wang Jinbin, Li Peng, Shi Wei, Zhu Hong, Lv Jianjun, Zhao Xiao, Tang Xueming
Abstract excerpt
In this study, assessment of the safety of transgenic rice T1C-1 expressing Cry1C was carried out by: (1) studying horizontal gene transfer (HGT) in Sprague Dawley rats fed transgenic rice for 90 d; (2) examining the effect of Cry1C protein in vitro on digestibility and allergenicity; and (3) studying the changes of intestinal microbiota in rats fed with transgenic rice T1C-1 in acute and subchronic toxicity...
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