Article
Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells.
Oncotarget - 8 Nov 2016
Koch Katharina, Hartmann Rudolf, Schröter Friederike, Suwala Abigail Kora, Maciaczyk Donata, Krüger Andrea Caroline, Willbold Dieter, Kahlert Ulf Dietrich, Maciaczyk Jaroslaw
Abstract excerpt
Glioblastoma (GBM) is the most malignant brain tumor with very limited therapeutic options. Standard multimodal treatments, including surgical resection and combined radio-chemotherapy do not target the most aggressive subtype of glioma cells, brain tumor stem cells (BTSCs). BTSCs are thought to be responsible for tumor initiation, progression, and relapse. Furthermore, they have been associated with the...
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