Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2016

Alphonse Martin Prince, Duong Trang T, Shumitzu Chisato, Hoang Truong Long, McCrindle Brian W, Franco Alessandra, Schurmans Stéphane, Philpott Dana J, Hibberd Martin L, Burns Jane, Kuijpers Taco W, Yeung Rae S M

Abstract excerpt

Kawasaki disease (KD) is a multisystem vasculitis that predominantly targets the coronary arteries in children. Phenotypic similarities between KD and recurrent fever syndromes point to the potential role of inflammasome activation in KD. Mutations in NLRP3 are associated with recurrent fever/autoinflammatory syndromes. We show that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Vessels
Share to Inflammasomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-18

Share to Interleukin-1beta

Share to Mucocutaneous Lymph Node Syndrome

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Phosphotransferases (Alcohol Group Acceptor)

Source

Identifiers

PMID: 27694492
DOI: 10.4049/jimmunol.1600388

Genes

ITPKC
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease.PMID 27694492Read ↗

A critical appraisal of the role of intracellular Ca2+-signaling pathways in Kawasaki disease.Semantic proximity Read ↗

Kawasaki disease: novel insights into etiology and genetic susceptibility.Semantic proximity Read ↗

Integration of scRNA-Seq and bulk RNA-Seq uncover perturbed immune cell types and pathways of Kawasaki diseaseSemantic proximity Read ↗

ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.Semantic proximity Read ↗

Update of genetic susceptibility in patients with Kawasaki diseaseSemantic proximity Read ↗

Identification of susceptibility genes for Kawasaki disease.Semantic proximity Read ↗

Single-nucleotide polymorphism rs7251246 in ITPKC is associated with susceptibility and coronary artery lesions in Kawasaki disease.Semantic proximity Read ↗

Immunogenetics of Kawasaki disease.Semantic proximity Read ↗

Pharmacogenomics of coronary artery response to intravenous gamma globulin in kawasaki diseaseSemantic proximity Read ↗

Deciphering Kawasaki disease genetics through next generation sequencing: A scoping reviewSemantic proximity Read ↗

A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.Semantic proximity Read ↗

Kawasaki Disease: An update on Genetics and Pathophysiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.