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Article

Compromized DNA repair as a basis for identification of cancer radiotherapy patients with extreme radiosensitivity.

Cancer letters - 28 Dec 2016

Lobachevsky Pavel, Leong Trevor, Daly Patricia, Smith Jai, Best Nickala, Tomaszewski Jonathan, Thompson Ella R, Li Na, Campbell Ian G, Martin Roger F, Martin Olga A

Abstract excerpt

A small percentage of cancer radiotherapy patients develop abnormally severe side effects as a consequence of intrinsic radiosensitivity. We analysed the γ-H2AX response to ex-vivo irradiation of peripheral blood lymphocytes (PBL) and plucked eyebrow hair follicles from 16 patients who developed severe late radiation toxicity following radiotherapy, and 12 matched control patients. Longer retention of the γ-H2AX...

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Identifiers

PMID: 27693457
DOI: 10.1016/j.canlet.2016.09.010
PMCID: PMC5159273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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