Unravelling the role of epigenetics in reproductive adaptations to early-life environment.

doi:10.1038/s41574-020-0370-8

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Article

Unravelling the role of epigenetics in reproductive adaptations to early-life environment.

Nature reviews. Endocrinology - 1 Sept 2020

Bar-Sadeh Ben, Rudnizky Sergei, Pnueli Lilach, Bentley Gillian R, Stöger Reinhard, Kaplan Ariel, Melamed Philippa

Abstract excerpt

Reproductive function adjusts in response to environmental conditions in order to optimize success. In humans, this plasticity includes age of pubertal onset, hormone levels and age at menopause. These reproductive characteristics vary across populations with distinct lifestyles and following specific childhood events, and point to a role for the early-life environment in shaping adult reproductive trajectories....

Topics

Adaptation, Physiological
Aging
Animals
DNA Methylation
Environment
Epigenesis, Genetic
Female
Fertility
Fetal Development
Humans
Life Style

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Maternal Nutritional Physiological Phenomena

Phenotype

Pregnancy

Progesterone

Puberty

Reproduction

Source

Open in PubMed

Identifiers

PMID: 32620937
DOI: 10.1038/s41574-020-0370-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32620937-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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