Article
Immunostimulatory membrane proteins potentiate H. pylori-induced carcinogenesis by enabling CagA translocation.
Gut microbes - 1 Jan 2000
Varga Matthew G, Wood Cecily R, Butt Julia, Ryan Mackenzie E, You Wei-Cheng, Pan Kaifeng, Waterboer Tim, Epplein Meira, Shaffer Carrie L
Abstract excerpt
Infection with Helicobacter pylori is the single greatest risk factor for developing gastric adenocarcinoma. In prospective, population-based studies, seropositivity to the uncharacterized H. pylori proteins Hp0305 and Hp1564 was significantly associated with cancer risk in East Asia. However, the mechanism underlying this observation has not been elucidated. Here, we show that Hp0305 and Hp1564 act in concert...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.