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Article

Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth.

Human molecular genetics - 1 Dec 2016

Brubaker Douglas, Liu Yu, Wang Junye, Tan Huiqing, Zhang Ge, Jacobsson Bo, Muglia Louis, Mesiano Sam, Chance Mark R

Abstract excerpt

Maternal genome influences associate with up to 40% of spontaneous preterm births (PTB). Multiple genome wide association studies (GWAS) have been completed to identify genetic variants associated with PTB. Disappointingly, no highly significant SNPs have replicated in independent cohorts so far. We developed an approach combining protein-protein interaction (PPI) network data with tissue specific gene expression...

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PMID: 27664809
DOI: 10.1093/hmg/ddw325
PMCID: PMC6078636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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