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Article

Novel Multiplex Fluorescent PCR-Based Method for HLA Typing and Preimplantational Genetic Diagnosis of β-Thalassemia.

Archives of medical research - 1 May 2016

Khosravi Sharifeh, Salehi Mansour, Ramezanzadeh Mahboobeh, Mirzaei Hamed, Salehi Rasoul

Abstract excerpt

BACKGROUND AND AIMS: Thalassemia is curable by bone marrow transplantation; however, finding suitable donors with defined HLA combination remains a major challenge. Cord blood stem cells with preselected HLA system through preimplantation genetic diagnosis (PGD) proved very useful for resolving scarce HLA-matched bone marrow donors. METHODS: A thalassemia trait couple with an affected child was included in this...

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PMID: 27664489
DOI: 10.1016/j.arcmed.2016.07.006

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PGD

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