Endotypes of Vascular Health Predict Transplantation-Free Survival in Pulmonary Hypertension.

doi:10.1161/JAHA.125.048795

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Article

Endotypes of Vascular Health Predict Transplantation-Free Survival in Pulmonary Hypertension.

Journal of the American Heart Association - 21 Jul 2026

Farha Samar, Hu Bo, Chen Ruoying, Barnard John, Comhair Suzy, Heresi Gustavo, Parambil Joseph, Tonelli Adriano, Beck Gerald, Berman-Rosenzweig Erika, DuBrock Hilary, Finet J Emanuel, Frantz Robert P, Grunig Gabriele, Hassoun Paul M, Hemnes Anna R, Hill Nicholas, Horn Evelyn, Jellis Christine, Leopold Jane A, Park Margaret M, Rischard Franz P, Simpson Catherine, Tang W H Wilson, Olman Mitchell A, Erzurum Serpil C, Dweik Raed A

Abstract excerpt

BACKGROUND: The current classification of pulmonary hypertension (PH), based largely on expert opinion, has limitations in prognostication and guiding therapies. We hypothesize that novel PH clusters that predict survival will reveal mechanistic phenotypes associated with biomarkers of vascular health across all PH groups. METHODS: We first identify novel PH clinical clusters by performing unsupervised clustering...

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PMID: 42466490
DOI: 10.1161/JAHA.125.048795
PMCID: PMC13477274

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