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Article

Are carriers of CYP21A2 mutations less vulnerable to psychological stress? A population-based national cohort study.

Clinical endocrinology - 1 Mar 2017

Nordenström Anna, Butwicka Agnieszka, Lindén Hirschberg Angelica, Almqvist Catarina, Nordenskjöld Agneta, Falhammar Henrik, Frisén Louise

Abstract excerpt

BACKGROUND: Congenital adrenal hyperplasia (CAH) is one of the most common monogenic autosomal recessive disorders with an incidence of one in 15 000. About one in 70 individuals in the general population are carriers of a severe CYP21A2 mutation. It has been suggested that this confers a survival advantage, perhaps as a result of increased activity in the hypothalamic-pituitary-adrenal axis. We investigated...

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PMID: 27654981
DOI: 10.1111/cen.13242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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