Article
Interleukin-1: Ariadne's Thread in Autoinflammatory and Autoimmune Disorders.
The Israel Medical Association journal : IMAJ - 1 Feb 2015
Cantarini Luca, Lopalco Giuseppe, Cattalini Marco, Vitale Antonio, Galeazzi Mauro, Rigante Donato
Abstract excerpt
Autoinflammatory and autoimmune disorders are characterized by chronic activation of the immune system, which leads to systemic self-directed inflammation in genetically predisposed individuals. Mutations in inflammasome-related proteins have been associated with autoinflammatory disorders, and the link between inflammasome and autoimmune disorders is becoming increasingly clear. As researchers learn more about...
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