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Influence of a novel histone deacetylase inhibitor panobinostat (LBH589) on the growth of ovarian cancer

15 Sept 2016

Abstract excerpt

BACKGROUND: Pre-clinical studies have demonstrated that natural and synthetic histone deacetylase (HDAC) inhibitors can impede the in vitro and in vivo growth of cell lines from a variety of gynecologic and other malignancies. We investigated the anti-tumor activity of panobinostat (LBH589) both in vitro and in vivo as either a single agent or in combination with conventional cytotoxic chemotherapy using...

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PMID: 27633667
DOI: 10.1186/s13048-016-0267-2

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