Article
inFRank: a ranking-based identification of influential genes in biological networks.
Oncotarget - 4 Jul 2017
Cui Xiuliang, Li Xiaofeng, Li Jing, Wang Xue, Sun Wen, Cheng Zhuo, Ding Jin, Wang Hongyang
Abstract excerpt
Capturing the predominant driver genes is critical in the analysis of high-throughput experimental data; however, existing methods scarcely include the unique characters of biological networks. Herein we introduced a ranking-based computational framework (inFRank) to rank the proteins by their influence. Using inFRank, we identified the top 20 influential genes in hepatocellular carcinoma (HCC). Network analysis...
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