Article
MicroRNA-126 increases chemosensitivity in drug-resistant gastric cancer cells by targeting EZH2.
Biochemical and biophysical research communications - 7 Oct 2016
Wang Ping, Li Ziqiu, Liu Haide, Zhou Dongmei, Fu Aiqin, Zhang Enning
Abstract excerpt
Chemotherapeutic insensitivity is a significant barrier for effective treatment of gastric cancer (GC). Recently, emerging evidence has demonstrated that microRNAs (miRNAs) are critically involved in drug resistance. Here, by a large-scale screen, we noticed low expression of miR-126 in the drug-resistant GC cell lines SGC7901/VCR and SGC7901/ADR compared with their parental cell line SGC7901. Ectopic expression...
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