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Inhibition of c-Myc by let-7b mimic reverses mutidrug resistance in gastric cancer cells

28 Jan 2015

Abstract excerpt

Chemotherapy is one of the few effective choices for patients with advanced or recurrent gastric cancer (GC). However, the development of mutidrug resistance (MDR) to cancer chemotherapy is a major obstacle to the effective treatment of advanced GC. Additionally, the mechanism of MDR remains to be determined. In the present study, we tested IC50 of cisplatin (DDP), vincristine (VCR) and 5-fluorouracil (5-FU) in...

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PMID: 25633261
DOI: 10.3892/or.2015.3757

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