Article
HLA-G profile of infertile couples who underwent assisted reproduction treatment.
Human immunology - 1 Dec 2016
Costa Cynthia Hernandes, Gelmini Georgia Fernanda, Nardi Fabiola Silva, Roxo Valéria Maria Munhoz Sperandio, Schuffner Alessandro, da Graça Bicalho Maria
Abstract excerpt
HLA-G codes for a non-classical class I (Ib) protein which is mainly expressed in trophoblast cells. Many pieces of evidence pointed out its essential role conferring immunological tolerance to the fetus. Some HLA-G alleles have been linked to enhanced or reduced HLA-G protein levels expression, which have been associated with reproductive failure. In this study 33 couples undergoing ART (assisted reproduction...
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