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Article

Germline <i><scp>PMS</scp>2</i> mutation screened by mismatch repair protein immunohistochemistry of colorectal cancer in Japan

2 Sept 2016

Abstract excerpt

Germline PMS2 gene mutations were detected by RT-PCR/direct sequencing of total RNA extracted from puromycin-treated peripheral blood lymphocytes (PBL) and multiplex ligation-dependent probe amplification (MLPA) analyses of Japanese patients with colorectal cancer (CRC) fulfilling either the revised Bethesda Guidelines or being an age at disease onset of younger than 70 years, and screened by mismatch repair...

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PMID: 27589204
DOI: 10.1111/cas.13073

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