Article
A new method for identifying causal genes of schizophrenia and anti-tuberculosis drug-induced hepatotoxicity.
Scientific reports - 1 Sept 2016
Huang Tao, Liu Cheng-Lin, Li Lin-Lin, Cai Mei-Hong, Chen Wen-Zhong, Xu Yi-Feng, O'Reilly Paul F, Cai Lei, He Lin
Abstract excerpt
Schizophrenia (SCZ) may cause tuberculosis, the treatments for which can induce anti-tuberculosis drug-induced hepatotoxicity (ATDH) and SCZ-like disorders. To date, the causal genes of both SCZ and ATDH are unknown. To identify them, we proposed a new network-based method by integrating network random walk with restart algorithm, gene set enrichment analysis, and hypergeometric test; using this method, we...
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