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Article

Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections.

American journal of human genetics - 1 Sept 2016

Guo Dong-Chuan, Grove Megan L, Prakash Siddharth K, Eriksson Per, Hostetler Ellen M, LeMaire Scott A, Body Simon C, Shalhub Sherene, Estrera Anthony L, Safi Hazim J, Regalado Ellen S, Zhou Wei, Mathis Michael R, Eagle Kim A, Yang Bo, Willer Cristen J, Boerwinkle Eric, Milewicz Dianna M

Abstract excerpt

Acute aortic dissections are a preventable cause of sudden death if individuals at risk are identified and surgically repaired in a non-emergency setting. Although mutations in single genes can be used to identify at-risk individuals, the majority of dissection case subjects do not have evidence of a single gene disorder, but rather have the other major risk factor for dissections, hypertension. Initial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27569546
DOI: 10.1016/j.ajhg.2016.06.034
PMCID: PMC5011062

Genes

ULK4
LRP1
FBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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