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Article

Erlotinib plus bevacizumab as an effective treatment for leptomeningeal metastases from EGFR mutation-positive non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2016

Sakata Yoshihiko, Kawamura Kodai, Shingu Naoki, Ichikado Kazuya

Abstract excerpt

Leptomeningeal metastasis is a severe complication of non-small cell lung cancer. Its prognosis is very poor and conventional treatments have limited efficacy. However, epidermal growth factor receptor-tyrosine kinase inhibitors have exhibited high response rates in EGFR mutation-positive lung cancer patients with central nervous system metastases. It has been postulated that this could be due to the penetration...

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Identifiers

PMID: 27565925
DOI: 10.1016/j.lungcan.2016.07.008

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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