Article
Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2016
Shien Kazuhiko, Papadimitrakopoulou Vassiliki A, Wistuba Ignacio I
Abstract excerpt
Inhibitors of the programmed cell death 1 (PD-1) pathway show the potential to substantially increase the efficacy of therapy for various malignancies, including non-small cell lung cancer (NSCLC). At the same time, substantial effort has been invested in finding biomarkers predicting which patients will respond best to this immune checkpoint inhibition. PD-L1 expression in tumor cells and the tumor...
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