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Article

Cancer risk in DM1 is sex-related and linked to miRNA-200/141 downregulation.

Neurology - 20 Sept 2016

Fernández-Torrón Roberto, García-Puga Mikel, Emparanza José-Ignacio, Maneiro Miren, Cobo Ana-María, Poza Juan-José, Espinal Juan-Bautista, Zulaica Miren, Ruiz Irune, Martorell Loreto, Otaegui David, Matheu Ander, López de Munain Adolfo

Abstract excerpt

OBJECTIVE: Describe the incidence of cancer in a large cohort of patients with myotonic dystrophy type 1 (DM1) and to unravel the underlying molecular mechanisms. METHODS: Standardized incidence ratios (SIRs) were calculated in the Gipuzkoa DM1 cohort (1985-2013), dividing observed numbers by expected numbers for all cancers combined and stratified by sex. An estimation of the expected incidence was achieved by...

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PMID: 27558368
DOI: 10.1212/WNL.0000000000003124

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