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Article

Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline.

Oncotarget - 20 Dec 2016

Wang Tung Yuan, Peng Chih-Yu, Lee Shiuan-Shinn, Chou Ming-Yung, Yu Cheng-Chia, Chang Yu-Chao

Abstract excerpt

Oral squamous cell carcinoma (OSCC), one of the most deadliest malignancies in the world, is caused primarily by areca nut chewing in Southeast Asia. The mechanisms by which areca nut participates in OSCC tumorigenesis are not well understood. In this study, we investigated the effects of low dose long-term arecoline (10 μg/mL, 90-days), a major areca nut alkaloid, on enhancement cancer stemness of human oral...

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Identifiers

PMID: 27557511
DOI: 10.18632/oncotarget.11432
PMCID: PMC5356645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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