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Article

Acquired Resistance to First-Line Afatinib and the Challenges of Prearranged Progression Biopsies.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2016

Campo Meghan, Gerber David, Gainor Justin F, Heist Rebecca S, Temel Jennifer S, Shaw Alice T, Fidias Panos, Muzikansky Alona, Engelman Jeffrey A, Sequist Lecia V

Abstract excerpt

OBJECTIVES: The mechanisms of acquired resistance to the irreversible EGFR inhibitor afatinib are not well documented. We performed this prospective clinical trial to determine the prevalence of the mutation T790M in afatinib-resistant patients. METHODS: Eligible patients had EGFR mutations; they were tyrosine kinase inhibitor-naive and were treated with afatinib, 40 mg daily. At enrollment, patients consented to...

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Source

Identifiers

PMID: 27553514
DOI: 10.1016/j.jtho.2016.06.032

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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