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Article

The impact of H63D HFE gene carriage on hemoglobin and iron status in children.

Annals of hematology - 1 Dec 2016

Barbara Kaczorowska-Hac, Marcin Luszczyk, Jedrzej Antosiewicz, Wieslaw Ziolkowski, Elzbieta Adamkiewicz-Drozynska, Malgorzata Mysliwiec, Ewa Milosz, Jacek Kaczor Jan

Abstract excerpt

The molecular mechanism that regulates iron homeostasis is based on a network of signals, which reflect on the iron requirements of the body. Hereditary hemochromatosis is a heterogenic metabolic syndrome which is due to unchecked transfer of iron into the bloodstream and its toxic effects on parenchymatous organs. It is caused by the mutation of genes that encode proteins that help hepcidin to monitor serum...

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Source

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Identifiers

PMID: 27553379
DOI: 10.1007/s00277-016-2792-x
PMCID: PMC5093215

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The impact of H63D HFE gene carriage on hemoglobin and iron status in children.PMID 27553379Read ↗

[Hfeprotein impact on iron metabolism].Semantic proximity Read ↗

HFE Gene Mutations and Iron Status in 100 Healthy Polish Children.Semantic proximity Read ↗

H63D Syndrome: A rare clinical phenotype caused by a homozygous mutation of HFE gene H63DSemantic proximity Read ↗

Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants.Semantic proximity Read ↗

Incidence of a clinically relevant H63D syndrome in carriers of a homozygous mutation of HFE gene H63DSemantic proximity Read ↗

From Environment to Genome and Back: A Lesson from HFE Mutations.Semantic proximity Read ↗

Modifying factors of the HFE hemochromatosis phenotype.Semantic proximity Read ↗

HFE gene mutations in patients with altered iron metabolism in Argentina.Semantic proximity Read ↗

Population-based analysis of the frequency of HFE gene polymorphisms: Correlation with the susceptibility to develop hereditary hemochromatosis.Semantic proximity Read ↗

A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism.Semantic proximity Read ↗

HFE gene: Structure, function, mutations, and associated iron abnormalities.Semantic proximity Read ↗

Haemochromatosis in children: A national retrospective cohort promoted by the A.I.E.O.P. (Associazione Italiana Emato-Oncologia Pediatrica) study group.Semantic proximity Read ↗

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