Article
Population-based analysis of the frequency of HFE gene polymorphisms: Correlation with the susceptibility to develop hereditary hemochromatosis.
Molecular medicine reports - 1 Jul 2016
Katsarou Martha-Spyridoula, Latsi Rosana, Papasavva Maria, Demertzis Nikolaos, Kalogridis Thodoris, Tsatsakis Aristides M, Spandidos Demetrios A, Drakoulis Nikolaos
Abstract excerpt
Hereditary hemochromatosis (HH) is an autosomal recessive genetic disease, characterized by increased dietary iron absorption. Due to the absence of an effective excretory mechanism, the excess iron in the body may accumulate resulting in toxic effects. The HFE gene also affects the activity of hepcidin, a hormone which acts as a negative regulator of iron metabolism. In this study, we performed a...
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