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Article

A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism.

European journal of human genetics : EJHG - 1 Mar 2003

Njajou Omer T, Houwing-Duistermaat Jeanine J, Osborne Richard H, Vaessen Norbert, Vergeer Jeanette, Heeringa Jan, Pols Huibert A P, Hofman Albert, van Duijn Cornelia M

Abstract excerpt

The C282Y and H63D mutations in the HFE gene are important causes of hemochromatosis. In the elderly, these mutations might be associated with increased morbidity because of the lifelong accumulation of iron. In a population-based sample of the elderly, we determined the value of genotyping for H...

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Source

Identifiers

PMID: 12673276
DOI: 10.1038/sj.ejhg.5200955

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12673276-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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