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Article

Applying the Lessons of Tuberous Sclerosis: The 2015 Hower Award Lecture.

Pediatric neurology - 1 Oct 2016

Roach E Steve

Abstract excerpt

Tuberous sclerosis complex is a dominantly inherited disorder that variably affects the brain, skin, kidneys, heart, and other organs. Its neurological manifestations include epilepsy, autism, cognitive and behavioral dysfunction, and giant cell tumors. A mutation of either TSC1 or TSC2 can cause tuberous sclerosis complex. Their two gene products, hamartin and tuberin, form a physical complex which normally...

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Identifiers

PMID: 27543366
DOI: 10.1016/j.pediatrneurol.2016.07.003

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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