Article
Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model.
Cell death & disease - 18 Aug 2016
Palombo R, Savini I, Avigliano L, Madonna S, Cavani A, Albanesi C, Mauriello A, Melino G, Terrinoni A
Abstract excerpt
The epidermis is a dynamic tissue in which keratinocytes proliferate in the basal layer and undergo a tightly controlled differentiation while moving into the suprabasal layers. The balance between keratinocyte proliferation, differentiation, and death is essential, and its perturbation can result in pathological changes. Some common skin diseases, such as psoriasis, are characterized by hyperproliferation...
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