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Article

Transcriptional regulation of mammalian autophagy at a glance

15 Aug 2016

Abstract excerpt

Macroautophagy, hereafter referred to as autophagy, is a catabolic process that results in the lysosomal degradation of cytoplasmic contents ranging from abnormal proteins to damaged cell organelles. It is activated under diverse conditions, including nutrient deprivation and hypoxia. During autophagy, members of the core autophagy-related (ATG) family of proteins mediate membrane rearrangements, which lead to...

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PMID: 27528206
DOI: 10.1242/jcs.188920

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