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Gifted microbes for genome mining and natural product discovery

12 Aug 2016

Abstract excerpt

Actinomycetes are historically important sources for secondary metabolites (SMs) with applications in human medicine, animal health, and plant crop protection. It is now clear that actinomycetes and other microorganisms with large genomes have the capacity to produce many more SMs than was anticipated from standard fermentation studies. Indeed ~90 % of SM gene clusters (SMGCs) predicted from genome sequencing are...

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PMID: 27520548
DOI: 10.1007/s10295-016-1815-x

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