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The Discovery of Reverse Transcriptase

2 Aug 2016

Abstract excerpt

In 1970 the independent and simultaneous discovery of reverse transcriptase in retroviruses (then RNA tumor viruses) by David Baltimore and Howard Temin revolutionized molecular biology and laid the foundations for retrovirology and cancer biology. In this historical review we describe the formulation of the controversial provirus hypothesis by Temin, which ultimately was proven by his discovery of reverse...

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PMID: 27482900
DOI: 10.1146/annurev-virology-110615-035556

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