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Article

Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study.

The American journal of clinical nutrition - 1 Sept 2016

Kim Shana J, Zuchniak Anna, Sohn Kyoung-Jin, Lubinski Jan, Demsky Rochelle, Eisen Andrea, Akbari Mohammad R, Kim Young-In, Narod Steven A, Kotsopoulos Joanne

Abstract excerpt

BACKGROUND: B vitamins [vitamins B-6, B-9 (folate), and B-12] play important roles in nucleotide biosynthesis and biological methylation reactions, aberrancies of which have all been implicated in carcinogenesis. In the general population, evidence has suggested that high circulating folate and folic acid (synthetic form of folate) supplement use may increase breast cancer risk, but the role of folate in...

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Source

Identifiers

PMID: 27465373
DOI: 10.3945/ajcn.116.133470

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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