Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.

doi:10.1007/s13277-016-5178-8

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Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2016

Starska Katarzyna, Forma Ewa, Jóźwiak Paweł, Lewy-Trenda Iwona, Danilewicz Marian, Stasikowska-Kanicka Olga, Skóra Michał, Kolary Katarzyna, Miazga Jakub, Krześlak Anna, Bryś Magdalena

Abstract excerpt

Recent evidence indicates the involvement of calpains (CAPNs), a family of cysteine proteases, in cancer development and progression, as well as the insufficient response to cancer therapies. The contribution of CAPNs and regulatory calpastatin (CAST) and ERK1/2 kinases to aggressiveness, disease course, and outcome in laryngeal cancer remains elusive. This study was aimed to evaluate the CAPN1/2-CAST-ERK1/2...

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Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.

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