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Article

Regulation of Schwann cell proliferation and migration by miR-1 targeting brain-derived neurotrophic factor after peripheral nerve injury.

Scientific reports - 6 Jul 2016

Yi Sheng, Yuan Ying, Chen Qianqian, Wang Xinghui, Gong Leilei, Liu Jie, Gu Xiaosong, Li Shiying

Abstract excerpt

Peripheral nerve injury is a global problem that causes disability and severe socioeconomic burden. Brain-derived neurotrophic factor (BDNF) benefits peripheral nerve regeneration and becomes a promising therapeutic molecule. In the current study, we found that microRNA-1 (miR-1) directly targeted BDNF by binding to its 3'-UTR and caused both mRNA degradation and translation suppression of BDNF. Moreover, miR-1...

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Identifiers

PMID: 27381812
DOI: 10.1038/srep29121
PMCID: PMC4933896

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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