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Multiplex APLP System for High-Resolution Haplogrouping of Extremely Degraded East-Asian Mitochondrial DNAs.

PloS one - 1 Jan 2016

Kakuda Tsuneo, Shojo Hideki, Tanaka Mayumi, Nambiar Phrabhakaran, Minaguchi Kiyoshi, Umetsu Kazuo, Adachi Noboru

Abstract excerpt

Mitochondrial DNA (mtDNA) serves as a powerful tool for exploring matrilineal phylogeographic ancestry, as well as for analyzing highly degraded samples, because of its polymorphic nature and high copy numbers per cell. The recent advent of complete mitochondrial genome sequencing has led to improved techniques for phylogenetic analyses based on mtDNA, and many multiplex genotyping methods have been developed for...

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Identifiers

PMID: 27355212
DOI: 10.1371/journal.pone.0158463
PMCID: PMC4927117

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