Antibacterial Efficacy of Eravacycline <i>In Vivo</i> against Gram-Positive and Gram-Negative Organisms

Abstract excerpt

Members of the tetracycline class are frequently classified as bacteriostatic. However, recent findings have demonstrated an improved antibacterial killing profile, often achieving ≥3 log10 bacterial count reduction, when such antibiotics have been given for periods longer than 24 h. We aimed to study this effect with eravacycline, a novel fluorocycline, given in an immunocompetent murine thigh infection model...