Article
Enzyme-Catalyzed Asymmetric Domino Thia-Michael/Aldol Condensation Using Pepsin.
The Journal of organic chemistry - 15 Jul 2016
Xiang Yang, Song Jian, Zhang Yong, Yang Da-Cheng, Guan Zhi, He Yan-Hong
Abstract excerpt
The novel catalytic promiscuity of pepsin from porcine gastric mucosa for the asymmetric catalysis of the domino thia-Michael/aldol condensation reaction in MeCN and buffer was discovered for the first time. Broad substrate specificity was tested, and a series of corresponding products were obtained with enantioselectivities of up to 84% ee. This specific catalysis was demonstrated by using recombinant pepsin and...
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