Article
Generation of KCL018 research grade human embryonic stem cell line carrying a mutation in the DMPK gene.
Stem cell research - 1 Mar 2016
Miere Cristian, Hewitson Heema, Devito Liani, Wood Victoria, Kadeva Neli, Cornwell Glenda, Codognotto Stefano, Stephenson Emma, Ilic Dusko
Abstract excerpt
The KCL018 human embryonic stem cell line was derived from an embryo donated for research that carried an autosomal dominant mutation affecting one allele of the DMPK gene encoding the dystrophia myotonica protein kinase (2200 trinucleotide repeats; 14 for the normal allele). The ICM was isolated using laser microsurgery and plated on γ-irradiated human foreskin fibroblasts. Both the derivation and cell line...
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