Article
Generation of KCL027 research grade human embryonic stem cell line carrying a mutation in the HTT gene.
Stem cell research - 1 Mar 2016
Jacquet Laureen, Hewitson Heema, Wood Victoria, Kadeva Neli, Cornwell Glenda, Codognotto Stefano, Hobbs Carl, Stephenson Emma, Ilic Dusko
Abstract excerpt
The KCL027 human embryonic stem cell line was derived from an embryo donated for research that carried an autosomal dominant mutation affecting one allele of the HTT gene encoding huntingtin (43 trinucleotide repeats; 21 for the normal allele). The ICM was isolated using laser microsurgery and plated on γ-irradiated human foreskin fibroblasts. Both the derivation and cell line propagation were performed in an...
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