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Article

Generation of KCL017 research grade human embryonic stem cell line carrying a mutation in VHL gene.

Stem cell research - 1 Mar 2016

Hewitson Heema, Wood Victoria, Kadeva Neli, Cornwell Glenda, Codognotto Stefano, Stephenson Emma, Ilic Dusko

Abstract excerpt

The KCL017 human embryonic stem cell line was derived from an embryo donated for research that carried an autosomal dominant mutation affecting splicing site of the VHL gene encoding von Hippel-Lindau tumor suppressor E3 ubiquitin protein ligase (676+3A>T). The ICM was isolated using laser microsurgery and plated on γ-irradiated human foreskin fibroblasts. Both the derivation and cell line propagation were...

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Source

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Identifiers

PMID: 27345980
DOI: 10.1016/j.scr.2016.01.013
PMCID: PMC4823763

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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