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Article

Generation of a human iPSC line from a patient with a defect of intergenomic communication.

Stem cell research - 1 Jan 2016

Zurita Francisco, Galera Teresa, González-Páramos Cristina, Moreno-Izquierdo Ana, Schneiderat Peter, Fraga Mario F, Fernández Agustin F, Garesse Rafael, Gallardo M Esther

Abstract excerpt

Human iPSC line PG64SV.2 was generated from fibroblasts of a patient with a defect of intergenomic communication. This patient harbored a homozygous mutation (c.2243G>C; p.Trp748Ser) in the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma gene (POLG). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non integrative methodology that involves the use of Sendai...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27345795
DOI: 10.1016/j.scr.2015.12.016

Genes

POLG

Variants

Provenance

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