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Impact of glycoprotein B genotype and naturally occurring ORF UL56 polymorphisms upon susceptibility of clinical human cytomegalovirus isolates to letermovir.

Antiviral research - 1 Aug 2016

Lischka Peter, Zhang Douglas, Holder Daniel, Zimmermann Holger

Abstract excerpt

Letermovir is a novel anti-HCMV drug in Phase III development that targets the UL56 subunit of the viral terminase complex. In immunocompromised patients four major glycoprotein B (gB) subtypes are known and may influence pathogenesis and thus disease outcomes. Using a panel of 74 letermovir-naïve, low-passage, clinical HCMV isolates, we examined the potential impact of i) gB genotype and ii) naturally occurring...

Topics

Acetates
Antiviral Agents
Cytomegalovirus
Cytomegalovirus Infections
Drug Resistance, Viral
Ganciclovir
Genotype
Humans
Microbial Sensitivity Tests
Mutation
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quinazolines

Viral Envelope Proteins

Viral Structural Proteins

Source

Identifiers

PMID: 27345658
DOI: 10.1016/j.antiviral.2016.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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