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Article

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.

eLife - 23 Jun 2016

Tsai Pei-Ling, Zhao Chenguang, Turner Elizabeth, Schlieker Christian

Abstract excerpt

Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis. LBR mutant derivatives implicated in Greenberg skeletal dysplasia or Pelger-Huët anomaly fail to rescue the cholesterol auxotrophy of a LBR-deficient human cell line, consistent with a loss-of-function mechanism...

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Identifiers

PMID: 27336722
DOI: 10.7554/eLife.16011
PMCID: PMC4951196

Genes

LBR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.PMID 27336722Read ↗

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